Dr. Mateusz Koptyra is the Research Lab Director in Center for Data Driven Discoveries in Biomedicine (D3b) at Children’s Hospital of Philadelphia.
Mateusz leads the coordination of Center’s wet bench workflows and pipelines and oversees implementation of wet bench scientific projects around the Center. His main work oscillates around specimens collection, handling storage and downstream processing, tumor models development, high throughput data generation and non-invasive diagnostics.
Mateusz’s team develops tissue specimen-derived tumor models that are currently shared by the Children’s Brain Tumor Tissue Consortium around the world. Independently, Mateusz’s research interests focus on non-invasive diagnostics and improvement of molecular profiling for pediatric brain tumors patients.
Mateusz earned an MS degree from Warsaw University and completed his PhD from the Medical University of Warsaw in Warsaw, Poland.
Awards and Recognitions
| 2019 | CBTTC Advisory Council Research Award from the Children’s Brain Tumor Tissue Consortium for the project “Pediatric Brain Tumor miRNA profiling for the Cohort of Children’s Brain Tumor Tissue Consortium specimens” |
| 2015 | Select Biosciences conference “Circulating DNA, circulating RNA, circulating tumor cells”. Best poster presentation, Boston, MA. |
| 2005 | Health Minister Award for series of experimental publications explaining mechanisms of proteasome inhibitor antitumor effect and grounds for genomic instability in cells transformed by oncogene – BCR/ABL, Warsaw, Poland. |
| 2004 | American Society of Hematology Conference. Travel Award, San Diego, CA. |
| 2001 | II Conference of Polish Science Society of Oncology. Best poster, Warsaw, Poland |
Recent and Notable Publications
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer.
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer.
Petralia F, Tignor N, Reva B, Koptyra M, Chowdhury S, Rykunov D, Krek A, Ma W, Zhu Y, Ji J, Calinawan A, Whiteaker JR, Colaprico A, Stathias V, Omelchenko T, Song X, Raman P, Guo Y, Brown MA, Ivey RG, Szpyt J, Guha Thakurta S, Gritsenko MA, Weitz KK, Lopez G, Kalayci S, Gümüş ZH, Yoo S, da Veiga Leprevost F, Chang HY, Krug K, Katsnelson L, Wang Y, Kennedy JJ, Voytovich UJ, Zhao L, Gaonkar KS, Ennis BM, Zhang B, Baubet V, Tauhid L, Lilly JV, Mason JL, Farrow B, Young N, Leary S, Moon J, Petyuk VA, Nazarian J, Adappa ND, Palmer JN, Lober RM, Rivero-Hinojosa S, Wang LB, Wang JM, Broberg M, Chu RK, Moore RJ, Monroe ME, Zhao R, Smith RD, Zhu J, Robles AI, Mesri M, Boja E, Hiltke T, Rodriguez H, Zhang B, Schadt EE, Mani DR, Ding L, Iavarone A, Wiznerowicz M, Schürer S, Chen XS, Heath AP, Rokita JL, Nesvizhskii AI, Fenyö D, Rodland KD, Liu T, Gygi SP, Paulovich AG, Resnick AC, Storm PB, Rood BR, Wang P; Children’s Brain Tumor Network; Clinical Proteomic Tumor Analysis Consortium.Cell. 2020 Dec 23;183(7):1962-1985.e31. doi: 10.1016/j.cell.2020.10.044. Epub 2020 Nov 25.PMID: 33242424 Free PMC article.
Sun CX, Daniel P, Bradshaw G, Shi H, Loi M, Chew N, Parackal S, Tsui V, Liang Y, Koptyra M, Adjumain S, Sun C, Chong WC, Fernando D, Drinkwater C, Tourchi M, Habarakada D, Sooraj D, Carvalho D, Storm PB, Baubet V, Sayles LC, Fernandez E, Nguyen T, Pörksen M, Doan A, Crombie DE, Panday M, Zhukova N, Dun MD, Ludlow LE, Day B, Stringer BW, Neeman N, Rubens JA, Raabe EH, Vinci M, Tyrrell V, Fletcher JI, Ekert PG, Dumevska B, Ziegler DS, Tsoli M, Syed Sulaiman NF, Loh AHP, Low SYY, Sweet-Cordero EA, Monje M, Resnick A, Jones C, Downie P, Williams B, Rosenbluh J, Gough D, Cain JE, Firestein R.Cancer Cell. 2023 Apr 10;41(4):660-677.e7. doi: 10.1016/j.ccell.2023.03.007. Epub 2023 Mar 30.PMID: 37001527 Free article.
Recent Developments in Blood Biomarkers in Neuro-oncology.
Foster JB, Koptyra MP, Bagley SJ.Curr Neurol Neurosci Rep. 2023 Dec;23(12):857-867. doi: 10.1007/s11910-023-01321-y. Epub 2023 Nov 9.PMID: 37943477
Radiomics for characterization of the glioma immune microenvironment.
Khalili N, Kazerooni AF, Familiar A, Haldar D, Kraya A, Foster J, Koptyra M, Storm PB, Resnick AC, Nabavizadeh A.NPJ Precis Oncol. 2023 Jun 19;7(1):59. doi: 10.1038/s41698-023-00413-9.PMID: 37337080 Free PMC article.
OpenPBTA: The Open Pediatric Brain Tumor Atlas.
Shapiro JA, Gaonkar KS, Spielman SJ, Savonen CL, Bethell CJ, Jin R, Rathi KS, Zhu Y, Egolf LE, Farrow BK, Miller DP, Yang Y, Koganti T, Noureen N, Koptyra MP, Duong N, Santi M, Kim J, Robins S, Storm PB, Mack SC, Lilly JV, Xie HM, Jain P, Raman P, Rood BR, Lulla RR, Nazarian J, Kraya AA, Vaksman Z, Heath AP, Kline C, Scolaro L, Viaene AN, Huang X, Way GP, Foltz SM, Zhang B, Poetsch AR, Mueller S, Ennis BM, Prados M, Diskin SJ, Zheng S, Guo Y, Kannan S, Waanders AJ, Margol AS, Kim MC, Hanson D, Van Kuren N, Wong J, Kaufman RS, Coleman N, Blackden C, Cole KA, Mason JL, Madsen PJ, Koschmann CJ, Stewart DR, Wafula E, Brown MA, Resnick AC, Greene CS, Rokita JL, Taroni JN; Children’s Brain Tumor Network; Pacific Pediatric Neuro-Oncology Consortium.Cell Genom. 2023 May 31;3(7):100340. doi: 10.1016/j.xgen.2023.100340. eCollection 2023 Jul 12.PMID: 37492101 Free PMC article.
A metagenomic analysis of the virome of inverted papilloma and squamous cell carcinoma.
Tong CCL, Lin X, Seckar T, Koptyra M, Kohanski MA, Cohen NA, Kennedy DW, Adappa ND, Papagiannopoulos P, Kuan EC, Baranov E, Jalaly JB, Feldman MD, Storm PB, Resnick AC, Palmer JN, Wei Z, Robertson ES.Int Forum Allergy Rhinol. 2023 Nov;13(11):2055-2062. doi: 10.1002/alr.23182. Epub 2023 May 28.PMID: 37189250